Program

Subject to change

Day 1: Tuesday

Tuesday, April 11, 2023

Registration Open	8:00 AM – 8:30 PM *Location: Atrium (Fourth Floor*
Pre-Conference Workshop: 3D Bioprinting of Functional Tissues *Location: Salon G (Fourth Floor)* Description: 3D Bioprinting has become an invaluable tool for regenerative medicine research. Of particular interest, are recent advances in bioprinting technology which allow for generation of biomimetic and functional tissues. The proposed workshop will cover recent advances in 3D bioprinting focusing on the use of smart biomaterials. Workshop Chair: Golnaz Karoubi	1:00 PM – 4:00 PM Break from 2:30 PM – 3:00 PM
Pre-Conference Workshop: Manufacturing Organs From Patient’s Own Cells: Where Are We And What It Will Take To Get Where We Want *Location: Salon A-D (Fourth Floor)* Description: This session will bring together experts in the field of organ engineering and will discuss the progress achieved so far and the hurdles to overcome before regenerative medicine will be able to deliver transplantable organs produced from patients’ own cells. This session will illustrate the state of the art of organ engineering, review the progress obtained so far in the field and identify a roadmap that should take us to the ultimate goal, namely the development of technologies that will enable solid organ bioengineering and manufacturing. Workshop Chair: Joan Schanck	1:00 PM – 4:00 PM Break from 2:30 PM – 3:00 PM
Transitional Break	4:00 PM – 4:15 PM
TERMIS-AM General Assembly Meeting Location: Salon E & F (Fourth Floor) All are invited to attend.	4:15 PM – 4:45 PM
TERMIS President and TERMIS-AM Chair Welcome Location: Salon E & F (Fourth Floor)	5:00 PM – 5:15 PM
Welcome from the TERMIS-AM 2023 Conference Co-Chairs Location: Salon E & F (Fourth Floor)	5:15 PM – 5:30 PM
Opening Plenary Panel: Reflecting on the Past, Living in the Present, and Envisioning the Future of Tissue Engineering for Human Health and Longevity Location: Salon E & F (Fourth Floor)	5:30 PM – 6:30 PM Panelists: Joseph P. Vacanti, MD; Sangeeta Bhatia, MD, PhD; Christopher S. Chen, MD, PhD; and Heather Prichard, PhD Moderator: Catherine F. Whittington PhD
Welcome Reception/Poster Session 1 Location: Gloucester (Third Floor)	6:30 PM – 8:30 PM

Day 2: Wednesday

Wednesday, April 12, 2023

Wednesday, April 12
Registration Open *Location: Atrium (Fourth Floor*)	6:00 AM – 8:00 PM
TWIGs Chairs Meeting Location: Arlington (Third Floor)	7:00 AM – 8:00 AM
Plenary Symposium 2: *Location: Salon E & F (Fourth Floor)*	8:00 AM – 9:00 AM Cellular Agriculture for a Healthy Planet and Healthy People Speaker: Dr. Marianne J. Ellis, University of Bath
TERMIS-AM Lifetime Achievement Award Presentation *Location: Salon E & F (Fourth Floor)*	9:00 AM – 9:30 AM Toward Bioengineering Translation Speaker: Kyriacos A. Athanasiou, PhD
Coffee Break in Exhibition Hall *Location: Gloucester (Third Floor)*	9:30 AM – 10:00 AM
Membership Committee Meeting *Location: Clarendon (Third Floor)*	9:30 AM – 10:00 AM
Scientific Concurrent Sessions 1	10:00 AM – 11:30 AM
Session 1: Business Plan Competition *Location: Salon H-K (Fourth Floor)* Session Chairs: Nicole Black & Milica Radisic	Presenters: Paula Puistola Mohammad Mir Mickael Dang Harald Ott Moo-Yeal Lee
Session 2: Mary Ann Liebert, Inc. publishers of Tissue Engineering, Parts A, B and C Session Exploring Healthcare Disparities and Solutions-Driven Approaches in Tissue Engineering and Regenerative Medicine *Location: Salon E (Fourth Floor)* Description: Healthcare disparities are often recognized as preventable differences in the prevalence, incidence, and burden of diseases within communities targeted by factors such as socioeconomic, gender, ethnic, or residential status. Within these targeted communities, access to meaningful healthcare, let alone contemporary biomedical procedures or treatments, are often unavailable or prohibitive. As one example, the lack of adequate medical equipment or the ability to sterilize tools or diagnose diseases leave members of these underserved communities without meaningful health care options. This workshop is dedicated to facilitating an open dialogue to discuss the necessary steps the TERM community is exploring in order to implement solutions-driven biomedical approaches to supporting these underserved communities. This workshop and discussion will be hosted by the Editorial Leadership of Tissue Engineering, published by Mary Ann Liebert, Inc., publishers, the official journal of TERMIS, in an expert panel discussion dedicated to the expansion and importance of supporting meaningful biomedical-driven health care solutions to underserved communities. Discussion topics include, but are not limited to: How can the TERM community support reducing healthcare disparities in underserved populations? How can we inspire, educate, and empower the biomedical engineering community to improve health care delivery around the world? What successes have we achieved in this area thus far and where can we make the biggest difference? Join us to discuss these topics together and more. The TERMIS and Tissue Engineering leadership teams strive to create a just and equitable environment from which to advance education and research in science, engineering, and medicine, and your participation and attendance of this workshop is essential to our dedication to our continued efforts. We look forward to seeing you at the workshop.	Participants: Dr. John Fisher, University of Maryland Dr. Antonios Mikos, Rice University Dr. Elizabeth Cosgriff Hernandez, University of Texas at Austin Sophie Reisz, VP & Executive Editor, Mary Ann Liebert, Inc.
Session 3: Emerging Technology Highlights – Melt Electrowriting and Extracellular Vesicles *Location: Salon G (Fourth Floor)* Session Chairs: Paul Dalton, Marley Dewey	Keynote Speaker: 10:00 AM – 10:30 AM – Micron-scale 3D Printing Using Melt Electrowriting (MEW) for Biomimetic Tissue Engineering Scaffold Fabrication Naomi Paxton Oral Presentation: 10:30 AM – 10:45 AM 1 Organized Melt-electrowritten Tubular Scaffolds To Build Vascularised Kidney Proximal Tubules A. van Genderen¹, M. de Ruijter², E. Al-Jehani¹, V. Kersten¹, M. G. Valverde¹, J. Malda², T. Vermonden¹, R. Masereeuw¹, J. Jansen³, M. Castilho⁴, S. Mihăilă¹; ¹Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, NETHERLANDS, ²Department of Orthopaedics, Utrecht Medical Center Utrecht, Utrecht University, Utrecht, NETHERLANDS, ³Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, GERMANY, ⁴Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, NETHERLANDS. Keynote Speaker: 10:45 AM – 11:15 AM – Engineering the Next Generation of Extracellular Vesicles: Lessons from Nature George Hussey Oral Presentation: 10:30 AM – 10:45 AM 156 Using Synthetic Matrix Vesicles To Induce In Vitro Osteogenic Mineralization T. Bina, P. Brudnicki, H. H. Lu; Columbia University, New York, NY.
Session 4: Micro/nano Biofabrication of Organ-on-chips, Organoids and Disease Models Location: Salon F (Fourth Floor) Session Chairs: Ruogang Zhao, HaeLin Jang SYIS Co-Chair: Jalili Sasan	Keynote Speaker: 10:00 AM – 10:30 AM – Biofabricating 3D Rissue Models to Study Vascular Dysfunction in Disease Alisa Morss Clyne 10:30 AM – 11:00 AM – TITLE TBD Deok-Ho Kim Rapid Fire Presentations: 11:00 AM – 11:05 AM 2 3d Bioprinted Liver-on-a-chip For Drug Cytotoxicity Screening J. Huh, H. Kang, J. S. Copus, C. E. Bishop, S. Soker, S. Murphy, T. D. Shupe, J. J. Yoo, A. Atala, S. Lee; Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 11:05 AM – 11:10 AM 3 Use Of Vascularized Heart-on-a-chip Platform To Identify Extracellular Vesicles From HUVEC As An Anti-inflammatory Treatment For SARS-COV-2 Acute Myocarditis R. Lu, N. Rafatian, M. Radisic; University of Toronto, Toronto, ON, Canada. 11:10 AM – 11:15 AM 4 Investigating Glioblastoma Tumor Cell Invasion And Treatment Using A Blood Brain Barrier On A Chip T. DePalma^1,2,A. Skardal^1,2; ¹Biomedical Engineering, The Ohio State University, Columbus, OH, ²The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, OH. 11:15 AM – 11:20 AM 5 RCAN1-4 Suppresses Metastatic Invasion And Tumor Cell Proliferation In A 3D Thyroid Metastasis-on-a-Chip Model K. Nairon¹, N. Rajan², M. Ringel², A. Skardal¹; ¹Biomedical Engineering, The Ohio State University, Columbus, OH, ²The Ohio State University, Columbus, OH. 11:20 AM – 11:25 AM 6 3d Perfusable Vascularized Model To Study Dengue Virus Ns1 Induced Endothelial Permeability And Dysfunction M. Rajput, A. Medina, S. Costmire, M. Song, M. Ferrer, E. Lee; NCATS/NIH, Rockville, MD. 11:25 AM – 11:30 AM 7 High Throughput Fabrication Of Biomimetic Fractal Topographical Substrates For High Fidelity Culture Of Kidney Podocytes C. Liu^1,2, K. Morton^3,4, K. Soon^3,4,1, S. Landau^1,2, K. Wagner^1,2, P. Aggarwal⁵, D. Bannerman^1,2, S. Pascual‐Gil², S. Okhovatian^1,2, X. Shen⁶, U. Broeckel⁵, T. Veres^3,4,1, M. Radisic^1,2; ¹University of Toronto, Toronto, ON, CANADA, ²University Health Network, Toronto, ON, CANADA, ³National Research Council Canada, Boucherville, QC, CANADA, ⁴Centre for Research and Applications in Fluidic Technologies, Toronto, ON, CANADA, ⁵Medical College of Wisconsin, Milwaukee, WI, ⁶McMaster University, Hamilton, ON, CANADA.
Transitional Break	11:30 AM – 11:45 AM
Women in TERM Networking Event (Ticketed Event) What Now? Addressing COVID Pandemic Challenges and Their Disproportional Impacts on Women *Location: Salon A-D (Fourth Floor)*	11:45 AM – 1:00 PM Pre–Registration Required. Ticketed Session Description: It has been well documented that gender inequities present continual challenges to women. During the COVID-19 pandemic, while all researchers were greatly impacted, it is well documented that women were disproportionally affected and this event served to further exacerbate these inequities¹. Emerging 3 years after the start of the pandemic, this lunch seeks to not only discuss these impacts but brainstorm on strategies for how to account for and mitigate their deleterious effects. All TERMIS-AM attendees are welcome to attend! We would particularly encourage attendees in leadership positions to learn and listen about these challenges and help us brainstorm concrete ways to ensure we engage and retain women in this discipline. ¹National Academies of Sciences, Engineering, and Medicine; Policy and Global Affairs; Committee on Women in Science, Engineering, and Medicine; Committee on Investigating the Potential Impacts of COVID-19 on the Careers of Women in Academic Science, Engineering, and Medicine; Eve Higginbotham and Maria Lund Dahlberg, Editors
Lunch (on your own)	11:45 AM – 1:00 PM
Transitional Break	1:00 PM – 1:15 PM
Jensen Tissue Engineering Award Presentation *Location: Salon E-F (Fourth Floor)*	1:15 PM – 2:00 PM Biomaterials in Tissue Engineering Speaker: Antonios Mikos, PhD
Transitional Break	2:00 PM – 2:15 PM
Scientific Concurrent Sessions 2	2:15 PM – 3:45 PM
Session 5: 3D Tissue-Engineered Cancer Models Part 2 *Location: Salon E (Fourth Floor)* Session Chairs: Rui Reis, David Kaplan SYIS Co-Chair: Rahul Madathiparambil Visalakshan	Keynote Speaker: 2:15 PM – 2:45 PM– Novel High-throughput Tissue Engineering Strategies for Better Understanding and Optimizing Biomaterial/cell Interactions and for Designing 3D Disease Models Rui Reis 2:45 PM – 3:05 PM – Self-assembled Vascular Network Model to Study Tumor Cell Arrest and Extravasation Roger Kamm 3:05 PM – 3:25 PM – 3D Bioprinted Cancer Organoids for Therapy Screening and Cell Biology Maria Kavallaris 3:25 PM – 3:45 PM – Collagen-based Scaffolds as 3D Models for Breast and Prostate Cancer Caroline Curtin
Session 6: Complex Organ Decellularization: How Close are We to Translation? *Location: Salon F (Fourth Floor)* Session Chairs: Giuseppe Orlando, Basak Uygun	Keynote Speaker: 2:15 PM – 2:45 PM – Building Livers for Transplantation Basak Uygun Oral Presentations: 2:45 PM – 3:00 PM 8 Decellularized Human Pancreatic Extracellular Matrix-based Physiomimetic Microenvironment For Human Islet Culture A. Asthana, D. Chaimov, R. Tamburrini, L. N. Byers, G. Orlando; WFIRM, Winston Salem, NC. 3:00 PM – 3:15 PM 9 Decellularization Of Heterogeneous Tissue: Mechanical And Structural Characterization Of Decellularized Trachea Components A. M. Greaney¹, A. B. Ramachandra¹, Y. Yuan², A. Korneva¹, J. D. Humphrey¹, L. E. Niklason³; ¹Department of Biomedical Engineering, Yale University, New Haven, CT, ²Department of Pulmonary, Critical Care & Sleep Medicine, Yale School of Medicine, New Haven, CT, ³Department of Anesthesiology, Yale School of Medicine, New Haven, CT. Rapid Fire Presentations: 3:15 PM – 3:20 PM 10 Bioengineered Liver Crosslinked With Nanographene Oxide Enables Efficient Liver Regeneration Via MMP Suppression And Immunomodulation D. Kim ¹, J. Ryu ¹,², K. Kang ¹, ¹ Adult Stem Cell Research Center and Research Institute for Veterinary Science, Seoul National University, Seoul, KOREA, REPUBLIC OF, ² Institute of Bio & Nano Convergence, Biogo Co. LTD, Seoul, KOREA, REPUBLIC OF 3:20 PM – 3:25 PM 11 Decellularized Composite Allografts Of Human Digits – A Step Towards Non-immunogenic Composite Allograft Transplantation M. E. McCarthy^1,2,3, I. Filz von Reiterdank^1,2,4, L. Charles^5,6,7, K. Uygun^1,2, A. G. Lellouch^5,6, C. L. Cetrulo, Jr.^5,6,2, B. E. Uygun^1,2; ¹Department of Surgery, Center for Engineering in Medicine and Surgery, Boston, MA, ²Shriners Hospitals for Children in Boston, Boston, MA, ³Department of General Surgery, Lahey Hospital and Medical Center, Burlington, MA, ⁴Division of Surgical Specialties, Department of Plastic Surgery and Hand Surgery, University Medical Center Utrecht, Utrecht, NETHERLANDS, ⁵Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA, ⁶Center for Transplantation Sciences, Vascularized Composite Allotransplantation Laboratory, Boston, MA, ⁷Department of Plastic Surgery, European George Pompidou Hospital, Paris, FRANCE. 3:25 PM – 3:30 PM 12 Alpha Gal Sugar Epitope Can’t Be Hidden Or Removed: Stays Immunogenic K. V. KURAVI¹, L. T. Sorrells¹, F. Rahaman¹, S. Choudhary², S. Commins², J. R. Bianchi¹; ¹Revivicor Inc. (Subsidiary of United Therapeutics), Blacksburg, VA, ²Div. of Allergy, Immunology, and Rheumatology, University of North Carolina, Chapel Hill, NC. 3:30 PM – 3:35 PM 13 Decellularization Of The Human Urethra For Tissue Engineering Applications M. Kuniakova^1,2, S. Ziaran^1,3, Z. Varchulova Novakova¹, M. Klein^1,4, K. Bevizova⁵, I. Varga^1,4, L. Danisovic^1,2; ¹National Institute of Rheumatic Diseases, Piestany, SLOVAKIA, ²Institute of Medical Biology, Genetics and Clinical Genetics, Comenius University, Faculty of Medicine, Bratislava, SLOVAKIA, ³Department of Urology, Comenius University, Faculty of Medicine, Bratislava, SLOVAKIA, ⁴Institute of Histology and Embryology, Comenius University, Faculty of Medicine, Bratislava, SLOVAKIA, ⁵Institute of Anatomy, Comenius University, Faculty of Medicine, Bratislava, SLOVAKIA. 3:35 PM – 3:40 PM 14 Decellularization: Leveraging A Tissue Engineering Technology For Food Production J. Jones; Engineering, Boston College, Chestnut Hill, MA. 3:40 PM – 3:45 PM 15 The Decellularized Human Dermal Matrix Is A Promising Biomaterial For The Construction Of Stand-alone Biological Scaffolds For Cardiac Regeneration F. Di Meglio¹, A. Sacco¹, V. Romano¹, I. Belviso¹, G. Ricci², A. Catizone³, D. Nurzynska⁴, F. Schonauer¹, C. Amarelli⁵, O. Casciello¹, C. Castaldo¹; ¹Public Health, University of Naples “Federico II”, Naples, ITALY, ²Experimental Medicine, Università della Campania Luigi Vanvitelli, Naples, ITALY, ³Anatomical Histological Medical Legal Sciences and Locomotor Apparatus, Sapienza University of Rome, Rome, ITALY, ⁴Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Naples “Federico II”, Baronissi, ITALY, ⁵Cardiovascular Surgery and Transplants, Monaldi Hospital, Naples, ITALY.
Session 7: Cardiovascular Devices *Location: Salon G (Fourth Floor)* Session Chairs: Feng Zhao, Brandon Tefft SYIS Co-Chair: Rana Ibrahim	Keynote Speakers: 2:15 PM – 2:45 PM– In vivo Tissue Engineering of Arteries Yadong Wang 2:45 PM – 3:15 PM – Engineering Biophysically Mimetic Scaffolds for Heart Valve Mechanobiology and Tissue Engineering K. Jane Grande-Allen Oral Presentations: 3:15 PM – 3:30 PM 16 Engineered Completely Biological Acellular Small-Diameter Vascular Grafts W. He¹, Y. Tseng², E. Wang², R. Bischof², R. Guillory¹, J. Goldman¹, F. Zhao²; ¹Michigan Tech University, Houghton, MI, ²Texas A&M University, College Station, TX. 3:30 PM – 3:45 PM 17 An Innovative Culturing Method Of An Alginate-based Hydrogel Aortic Valve Substitute With Native-like Geometry Y. Rioux¹, A. Bégin-Drolet¹, C. J. Hayward², Y. Maciel¹, J. Fradette^2,3, J. Ruel^1,2; ¹Department of Mechanical Engineering, Université Laval, Québec, QC, CANADA, ²Centre de Recherche en Organogénèse Expérimentale de l’Université Laval/LOEX, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, CANADA, ³Department of Surgery, Université Laval, Québec, QC, CANADA.
Session 8: Rapid Fire Session 1: Scaffolds/Biomaterials; Biofabrication & Bioreactors; Stem Cells/Neural *Location: Salon A-D (Fourth Floor)* Session Chairs: Molly Shoichet	Rapid Fire Presentations: 2:15 PM – 2:20 PM 18 Collagen Matrix Improves Cell-cell Connectivity And Contractility Compared To Fibrin Matrix In 3d Engineered Cardiac Tissue Strips D. Brenière-Letuffe¹, A. O. Wong², D. K. Lieu², K. D. Costa², R. A. Li²; ¹Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Fleminsberg, SWEDEN, ²Novoheart, Irvine, CA. 2:20 PM – 2:25 PM 19 Development Of Polyglobality Polymeric Nanoparticles Encapsulating A Photosensitizer And Functionalized With Bovine Serum Albumin For Application In Combined Phototherapy J. L. Oliveira, T. Agner, K. Cesca, C. Sayer, A. S. Immich; Departament of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, Florianópolis, BRAZIL. 2:25 PM – 2:30 PM 20 A Self-healing Hydrogel-based Delivery Of A Disease-modifying Drug Reduces Osteoarthritis Progression In Active Joints M. Dewani^1,2, J. Gao³, N. Joshi⁴; ¹Biosciences and bioengineering, Indian Institute of Technology, Mumbai, INDIA, ²Anesthesiology, Brigham and Women’s Hospital, Boston, MA, ³Brigham and Women’s Hospital, Boston, MA, ⁴Anethesiology, Brigham and Women’s Hospital, Boston, MA. 2:30 PM – 2:35 PM 21 3d Scaffolds From Agglomeration Of Collagen-gelatin Particles Associated With A Plant Extract Ofaloe Vera: Design, Elaboration And Physicochemical Characterization And In Vitro Biologicalperformance R. A. Jimenez^1,2, D. M. Millan², A. Sosnik³, M. R. Fontanilla⁴; ¹Chemistry-Program of Pharmacy, Universidad El Bosque, Bogota, COLOMBIA, ²Pharmacy, Universidad Nacional de Colombia, Bogota, COLOMBIA, ³Department of Materials Science and Engineering, Technion – Israel Institute of Technology, Haifa 3200003, ISRAEL, ⁴Chemistry-Program of Pharmacy, Universidad Nacional de Colombia, Bogota, COLOMBIA. 2:35 PM – 2:40 PM 22 Assessing Nerve Outcomes After Applying Collagen-Based Conduits In Open Wounds With Exposed Nerves C. R. Schuster¹, P. R. Keller¹, V. Soares¹, E. Reiche², V. Suresh¹, Y. Tan², V. Mroueh², J. Mroueh², S. Tuffaha¹, D. Coon²; ¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Division of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. 2:40 PM – 2:45 PM Q & A 2:45 PM – 2:50 PM 23 Mechanical Stimulation Enhances Tissue Engineered Blood Vessel Wall Thickness And Human Mesenchymal Stem Cell Differentiation W. DeMaria, A. Figueroa, M. Rolle; BME, Worcetser Polytechnic Institute, Worcester, MA. 2:50 PM – 2:55 PM 24 Development Of A Universal Bioreactor Platform For Regenerative Medicine Applications A. Mehta¹, P. Lee¹, E. Renteria¹, F. Marini¹, J. Kim¹, T. Criswell¹, T. Shupe¹, A. Atala¹, M. Gurcan², S. Soker¹, J. Hunsberger³, Y. Ju¹, J. Yoo¹; ¹Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, ²Center for Biomedical Informatics, Wake Forest School of Medicine, Winston-Salem, NC, ³RegenMed Development Organization, Winston-Salem, NC. 2:55 PM – 3:00 PM 25 Organ Chip Modeling Of Human Cervical Mucosa Physiology And Pathophysiology Z. Izadifar¹, J. Cotton¹, C. Chen², N. A. Bustos³, A. Stejskalova¹, C. Wu⁴, A. Gulati¹, N. T. LoGrande¹, A. M. Sesay¹, G. Goyal¹, K. Ribbeck⁴, C. Lebrilla², D. E. Ingber¹; ¹Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, ²Department of Chemistry, University of California, Davis, CA, ³Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, ⁴Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA. 3:00 PM – 3:05 PM 26 Towards A Generalizable 3D Engineered Model Of Human Tissue Fibrosis S. Shenk, L. Brown, S. Shook, J. Garlick; Diagnostic Sciences, Tufts University, Boston, MA. 3:05 PM – 3:10 PM 27 Customised Bioprinting Hardware Powered By Smart Ai – The Future of Customised Bioprinting as a Solution (cbaas)? A. Medikepura Anil; Next Big Innovation Labs, Bangalore, INDIA. 3:10 PM – 3:15 PM Q & A 3:15 PM – 3:20 PM 28 Biopreserved Human Tissue Engineered Nigrostriatal Pathway To Restore Axon Tracts In A Rat Model Of Parkinson’s Disease D. Chouhan¹, K. D. Browne¹, W. J. Gordián Vélez¹, S. Karandikar¹, R. Patel¹, B. Chau¹, R. B. Shultz¹, J. E. Duda², D. Cullen¹; ¹Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, ²Department of Neurology, University of Pennsylvania, Philadelphia, PA. 3:20 PM – 3:25 PM 29 Functional Characterization Of The Immunomodulatory Properties Of Human Urine-derived Stem Cells P. Yu, Y. Zhang; Wake Forest Institute for Regenerative Medicine, Winston Salem, NC. 3:25 PM – 3:30 PM 30 Single-Nuclei Multiomic Analysis Reveals Dynamic Regulation Of Endocrine Specification In Stem Cell-derived Islets M. Ishahak¹, E. E. Sanchez-Castro², P. Augsornworawat^1,3, J. Millman^1,3; ¹Division of Endocrinology, Metabolism & Lipid Research, Washington University in St. Louis, St. Louis, MO, ²Division of Biology & Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, ³Biomedical Engineering Department, Washington University in St. Louis, St. Louis, MO. 3:30 PM – 3:35 PM 31 Understanding Bone Regeneration Through Cellular Metabolic Adaptations J. Löffler¹, A. Noom¹, S. Kempa²,G. N. Duda¹; ¹Julius Wolff Institute, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, GERMANY, ²Berlin Institute for Medical Systems Biology at the Max Delbru Center, Berlin, GERMANY. 3:35 PM – 3:40 PM 32 Comprehensive Comparison Of Mesenchymal Stem Cells Derived From Four Different Sources V. Smolinska^1,2, M. Kuniakova^1,2, Z. Varchulova Novakova^1,2, A. Nicodemou^1,2, L. Danisovic^1,2; ¹Institute of Medical Biology, Genetics and Clinical Genetics, Comenius University of Bratislava, Bratislava, SLOVAKIA, ²National Institute of Rheumatic Diseases, Piestany, SLOVAKIA. 3:40 PM – 3:45 PM Q&A
Session 9: Dental and Craniofacial Part 1 *Location: Salon H-K (Fourth Floor)* Session Chairs: Sang Jin Lee, Weibo Zhang SYIS Co-Chair: Alexander Tatara	Keynote Speaker: 2:15 PM – 2:45 PM – Innovations for Bioengineering Maxillofacial Bone and Cartilage Tissue Mark Wong Oral Presentations: 2:45 PM – 3:00 PM 33 Regendogel: A Novel Tooth-derived Hydrogel For Pulp And Dentin Regeneration A. P. Bartolome¹, C. M. Franca¹, W. Zhang², S. Olson³, P. C. Yelick^2,3, L. E. Bertassoni^4,3; ¹Restorative Dentistry, CEDAR, Oregon Health & Science University, Portland, OR, ²Orthodontics, Tufts University School of Dental Medicine, Boston, MA, ³RegendoDent Inc., Ann Arbor, MI, ⁴Restorative Dentistry, Center for Regenerative Medicine, Biomedical Engineering, CEDAR, Oregon Health & Science University, Portland, OR. 3:00 PM – 3:15 PM 34 Hyperglycemia-regulated Dental Pulp Cells To Accelerate Bone Formation In In-vivo M. Kim, H. Eom, C. Park; Dental Biomaterials, Kyungpook National University, Daegu, KOREA, REPUBLIC OF. 3:15 PM – 3:30 PM 35 Scaffold-free Regenerative Approach For Temporomandibular Joint Repair F. P. Guastaldi¹, H. R. Matheus¹, H. Hadad¹, M. A. Randolph², R. W. Redmond³; ¹Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, ²Surgery, Massachusetts General Hospital, Boston, MA, ³Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA. 3:30 PM – 3:45 PM 36 Incorporating Strontium-containing Cryogels And Adipose-derived Stem Cells To Promote Alveolar Bone Regeneration In Osteoporosis G. Luo¹, C. Chen², J. Chen³; ¹Craniofacial Research Center and Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TAIWAN, ²Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Keelung, Keelung 204, TAIWAN, ³Department of Chemical and Materials Engineering, Chang Gung University, Guishan, TAIWAN.
Transitional Break	3:45 PM – 4:00 PM
Scientific Concurrent Sessions 3	4:00 PM – 5:30 PM
Session 10: Neural Tissue Engineering in Translation *Location: Salon H-K (Fourth Floor)* Session Chairs: Nisha Iyer, Courtney Dumont SYIS Co-Chair: Dimple Chouhan	Keynote Speaker: 4:00 PM – 4:30 PM– Peripheral Nerve Microphysiological Systems: Commercial Applications Michael Moore 4:30 PM – 5:00 PM – Bridging the Gap: Biomaterials and Neural Stem Cells in Spinal Cord Injury Aileen Anderson 5:00 PM – 5:30 PM – Repair and Regeneration of the Stroke-Damaged Brain Mike Modo
Session 11: Articular Cartilage Tissue Engineering & Translational *Location: Salon G (Fourth Floor)* Session Chairs: Tiago Fernandes, Sarah Greising SYIS Co-Chair: Gabriele Nasello	Keynote Speaker: 4:00 PM – 4:30 PM Clinical and Translational Aspects of Osteoarthritis and Chronic Joint Inflammation Christian Lattermann Oral Presentations: 4:30 PM – 4:45 PM 37 Effect Of Graphite Electrospun Scaffolds On Chondrocyte Gene Expression J. Z. Liu, J. L. McFaline-Figueroa, E. Azizi, H. H. Lu; Biomedical Engineering, Columbia University, New York, NY. 4:45 PM – 5:00 PM 38 Fast-crosslinking, High Stiffness, Cartilage-only Hydrogels E. A. Kiyotake¹, E. E. Thomas², C. Iribagiza¹, M. S. Detamore¹; ¹Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, ²Biomedical Engineering, University of Michigan, Ann Arbor, MI. 5:00 PM – 5:15 PM 39 A New Combinational Paradigm For Articular Cartilage Rejuvenation: Fractional Laser Treatment With Dynamic Self- Regenerating Cartilage F. P. Guastaldi¹, Y. Fan², R. C. Wu³, D. M. Kostyra³, Y. Wang³, W. A. Farinelli³, M. A. Randolph⁴, R. W. Redmond³; ¹Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, ⁴Surgery, Massachusetts General Hospital, Boston, MA. 5:15 PM – 5:30 PM 40 Microscale Strain Concentrations In Tissue-Engineered Osteochondral Implants Are Dictated By Local Composition And Architecture B. Kim¹, T. Kelly², H. Jung², O. S. Beane², S. Bhumiratana², I. Cohen³, L. J. Bonassar¹; ¹Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, ²EpiBone, Brooklyn, NY, ³Department of Physics, Cornell University, Ithaca, NY.
Session 12: Organoids and Microphysiological Systems *Location: Salon E (Fourth Floor)* Session Chairs: Pedro Costa, Julio Aleman SYIS Co-Chair: Allie Greaney	Oral Presentations: 4:00 PM – 4:15 PM 41 Cross-species Biomarker Identification For Drug Induced Vascular Injury Using A High-throughput Organ-on-chip Platform R. Gaibler, L. Hapach, T. Crawford, D. Matera, J. Charest, J. Walker, C. Williams; Bioengineering, The Charles Stark Draper Laboratory, Inc, Cambridge, MA. 4:15 PM – 4:30 PM 42 Development Of A Multi-Tissue Metastasis-on-a-Chip Platform To Study Metastasis Initiation And Invasion Kinetics K. Nairon¹, N. Rajan², M. Ringel², A. Skardal¹; ¹Biomedical Engineering, The Ohio State University, Columbus, OH, ²The Ohio State University, Columbus, OH. 4:30 PM – 4:45 PM 43 A New In Vitro Model Of Human Skin Vasculature For The Subcutaneous Space M. Proestaki¹, S. Zhang¹, R. D. Kamm^1,2; ¹Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, ²Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA. 4:45 PM – 5:00 PM 44 Development Of A Polarized Three-dimensional In Vitro Intestinal Tissue With Underlying Fibroblasts A. Massaro, C. Villegas-Novoa, Y. Wang, N. Allbritton; Bioengineering, University of Washington, Seattle, WA. 5:00 PM – 5:15 PM 45 Pillar And Perfusion Plate Platform For Robust Human Organoid Culture And Analysis M. Lee¹, S. Kang¹, S. Shrestha¹, P. Acharya¹, P. Joshi², V. K. Lekkala¹, M. Lee¹, M. Zolfaghar¹, N. Choi¹; ¹Biomedical Engineering, University of North Texas, Denton, TX, ²Bioprinting Laboratories Inc, Denton, TX. 5:15 PM – 5:30 PM 46 A Perfusable Ureteric Bud-on-chip Model K. J. Wolf, R. C. van Gaal, J. E. Rubins, K. T. Kroll, J. A. Lewis; Harvard University, Cambridge, MA.
Session 13: Skin Wound and Inflammation Part 1: Clinical **Location: Salon E (Fourth Floor) Session Chairs: Hasan Erbil Abaci, Alberto Pappalardo SYIS Co-Chair:** Logesh Kumar	Keynote Speaker: 4:00 PM – 4:30 PM– Hair Follicle Regeneration Following Wounding George Cotsarelis Oral Presentations: 4:30 PM – 4:45 PM 47 Wound Healing Regeneration By Testosterone Inhibition In A Murine And Porcine Model E. Reiche¹, V. Soares², Y. Tan¹, P. R. Keller², C. R. Schuster², V. Mroueh¹, J. Mroueh¹, D. Orgill¹, D. O’Brien-Coon¹; ¹Division of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Department of Plastic and Reconstructive Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD. 4:45 PM – 5:00 PM 48 A Regenerative Medicine Approach To Restore Estrogen Signaling In Older Adults’ Chronic Skin Wounds H. D. Zomer¹, P. Corey¹, C. McFetridge², S. Kim³, P. McFetridge², P. S. Cooke¹; ¹Physiological Sciences, University of Florida, Gainesville, FL, ²J. Crayton Pruitt Family Biomedical Engineering, University of Florida, Gainesville, FL, ³Small Animal Clinical Sciences, University of Florida, Gainesville, FL. 5:00 PM – 5:15 PM 49 Pre-organized Cellular Components In Bioprinted Skin Improving Long Term Functionality Of Full Thickness Wounds K. Willson¹, A. Gorkun², N. Mahajan¹, A. Jorgensen¹, C. Clouse¹, S. Soker¹, A. Atala¹; ¹Biomedical Engineering, Wake Forest University, WINSTON SALEM, NC, ²Wake Forest Institute for Regenerative Medicine, Wake Forest University, WINSTON SALEM, NC. 5:15 PM – 5:30 PM 50 Engineered Extracellular Vesicles With High Collagen-binding Affinity Present Superior In Situ Retention And Therapeutic Efficacy In Tissue Repair D. Hao, L. Lu, H. Song, Y. Duan, J. Chen, R. Carney, J. Li, P. Zhou, J. Nolta, K. Lam, K. Leach, D. Farmer, A. Panitch, A. Wang; University of California, Davis, Sacramento, CA.
Session 14: ASMB Symposium Engineering the Matrix for Healing Location: Salon A-D (Fourth Floor) Session Chairs: Ashley Brown, Daniel Abebayehu SYIS Co-Chair: Christopher Fellin	Keynote Speaker: 4:00 PM – 4:30 PM– Engineering Biomaterials to Address Neural Injury Sarah Stabenfeldt Oral Presentations: 4:30 PM – 4:45 PM 51 Depletion Of Cyr61/ccn1 From The Bone Marrow Stromal Niche Is A Potential Mechanism Contributing To The Dysregulation Of Mscs In Aging Skeletal Tissue M. Marinkovic^1,2, Q. Dai¹, A. O. Gonzalez¹, O. N. Tran¹, T. J. Block¹, S. E. Harris³, A. B. Salmon^4,5, C. Yeh^1,5, D. D. Dean¹, X. Chen^1,2; ¹Comprehensive Dentistry, University of Texas Health – San Antonio, San Antonio, TX, ²Research Service, South Texas Veterans Health Care System, San Antonio, TX, ³Periodontics, University of Texas Health – San Antonio, San Antonio, TX, ⁴Department of Molecular Medicine, University of Texas Health – San Antonio, San Antonio, TX, ⁵Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX. 4:45 PM – 5:00 PM 52 Mechanical Strength And Organization Of Collagen Matrix Of Infected Diabetic Wound Tissue Improved By Oxygenating And Antibacterial Macf Hydrogel Dressing Therapy H. A. Durr¹, S. Abri², S. Salinas³, R. Amini⁴, N. D. Leipzig⁵; ¹Integrated Biosciences, University of Akron, Akron, OH, ²Chemical, Biomolecular, and Corrosion Engineering, University of Akron, Akron, OH, ³Bioengineering, Northeastern Univeristy, Boston, MA, ⁴Bioengineering, Northeastern University, Boston, MA, ⁵Chemical, Biomolecular, and Corrosion Engineering, Integrated Biosciences, University of Akron, Akron, OH. 5:00 PM – 5:15 PM 53 Integration Of Cryogel And Electrospun Scaffolds Targeting The Bone-Tendon Attachment Site R. A. Millett, K. R. Hixon; Thayer School of Engineering, Dartmouth College, Hanover, NH. 5:15 PM – 5:30 PM 54 Novel Muscle- Or Bone-derived Hydrogels Promote Enhanced Tissue Repair In Volumetric Muscle Loss And Critical Bone Defect Models T. R. Kyriakides¹, Z. Chen², Y. Huang¹, H. Xing³, T. Tseng², F. Lee⁴; ¹Pathology and Biomedical Engineering, Yale University, New Haven, CT, ²Pathology, Yale University, New Haven, CT, ³Biomedical Engineering, Yale University, New Haven, CT, ⁴Orthopedics and Rehabilitation, Yale University, New Haven, CT.
Coffee Break in Exhibition Hall *Location: Gloucester (Third Floor)*	5:30 PM – 6:00 PM
Scientific Concurrent Sessions 4	6:00 PM – 7:30 PM
Session 15: Biofabrication of Multicellular Engineered Living Systems *Location: Salon G (Fourth Floor)* Session Chairs: Hyunjoon Kong, Eben Alsberg	Keynote Speaker: 6:00 PM – 6:26 PM – Engineering Complex Tissues via Cell-only Printing and 4D Systems Eben Alsberg 6:26 PM – 6:47 PM – Development of Horizontally Aligned Nanofibrous Hydrogel Films for 3D-like Neuronal Cell Cultures Myung Hwan Yoon 6:47 PM – 7:08 PM – Engineering the Biological Motor Control System Ritu Raman 7:08 PM – 7:30 PM – Engineering Neuron-innervating Skeletal Muscle in Vitro Hyun Joon
Session 16: Muscle Biology and Aging *Location: Salon A-D (Fourth Floor)* Session Chairs: Monty Montano, Alanna Gannon SYIS Co-Chair: Lexi Rindone	Keynote Speaker: 6:00 PM – 6:20 PM – Role of Biological Sex on Head and Neck Tissue Regeneration and Function Heidi Ann Kletzien 6:20 PM – 6:40 PM TBD Devin O’Brien-Coon 6:40 PM – 7:00 PM Modulators of Muscle Adaptation to Exercise and Functional Improvement Yori Endo Oral Presentations: 7:00 PM – 7:30 PM 55 Tissue-engineered Skeletal Muscle Containing Brown And White Adipocytes Using Muscle-derived Cells D. Leyton-Cifuentes, C. Mendiondo, C. Rathbone; Biomedical and Chemical Engineering, University of Texas at San Antonio, San Antonio, TX. 7:10 PM – 7:20 PM 56 Effect Of SIRT-1 Upregulation On Angiogenesis In Tissue Engineered Skeletal Muscle B. Sullivan¹, S. Pacelli², C. Rathbone¹; ¹University of Texas at San Antonio, San Antonio, TX, ²Illinois Institute of Technology, Chicago, IL. 7:20 PM – 7:30 PM 57 Exercise-Mediated Biochemical Signaling Guides Repair After Muscle Injury R. Raman; MIT, Cambridge, MA.
Session 17: Regenerative Rehabilitation – Functional Translation of Biologically Inspired Regenerative Technologies *Location: Salon F (Fourth Floor)* Session Chairs: Nick Willett, Fabrisia Ambrosio SYIS Co-Chair: Matthias Kollert	Keynote Speaker: 6:00 PM – 6:30 PM – Enhancing Stem Cell Therapeutics for Muscle Disorders Tom Rando 6:30 PM – 6:45 PM – Acellular Orthobiologics to Restore Musculoskeletal Structure and Function Brittany Taylor 6:45 PM – 7:00 PM – Mechanobiology of Regenerative Rehabilitation Joel Boerckel Oral Presentations: 7:00 PM – 7:15 PM 58 Engineered Human Skeletal Muscle With Physiologically-relevant Cellular Organization For Treatment Of Volumetric Muscle Loss B. Ayan¹, B. Oropeza¹, C. Hu², G. Chiang², T. Rando³, N. F. Huang¹; ¹Cardiothoracic Surgery, Stanford University, Stanford, CA, ²Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, ³Stanford University, Stanford, CA. 7:15 PM – 7:30 PM 59 Exploring The Combination Of Graphene Oxide Foams And Motor Training To Promote Regeneration At The Injured Spinal Cord E. Benayas¹, Y. Hernández², A. González-Mayorga², E. López-Dolado³, M. Serrano¹; ¹Department of Energy, Environment and Health, Instituto de Ciencia de Materiales de Madrid, CSIC, Madrid, SPAIN, ²Laboratory of Interfaces for Neural Repair, Hospital Nacional de Parapléjicos, Toledo, SPAIN, ³a) Laboratory of Interfaces for Neural Repair, Hospital Nacional de Parapléjicos, b) Research Unit of “Design and development of biomaterials for neural regeneration”, HNP-SESCAM, Joint Research Unit with CSIC, Toledo, SPAIN.
Session 18: Tissue Engineering Strategies for Pediatric Diseases and Disorders *Location: Salon H-K (Fourth Floor)* Session Chairs: Yi Hong, Aijun Wang SYIS Co-Chair: Julia Harrer	Keynote Speaker: 6:00 PM – 6:30 PM –3D Printed Pediatric Airway Scaffolds: Design to Pre-Clinical Studies to Clinical Outcomes and Back Again Scott Hollister Oral Presentations: 6:30 PM – 6:45 PM 60 Preclinical Evaluation Of Tissue Engineered Vascular Grafts W. E. Schwartzman¹, M. Nabavinia², A. Ulziibayar³, K. Blum¹, J. Kelly⁴, C. Breuer⁴; ¹The Ohio State University College of Medicine, Columbus, OH, ²Nationwide Children’s Hospital, Columbus, OH, 3Nationwide Children’s Hospital, Columbus, OH, ⁴Nationwide Children’s Hospital Abigail Wexner Research Institute, Columbus, OH. 6:45 PM – 7:00 PM 61 Developing A Combinational Stem Cell-based Tissue Engineering Approach To Treat Spina Bifida Before Birth D. Hao, S. Y. Lee, C. Pivetti, R. Gresham, R. Somoza, A. Hassan, P. Kumar, E. Kulubya, J. Jackson, M. Hernandez, K. Leach, A. Caplan, D. Farmer, A. Wang; University of California, Davis, Sacramento, CA. 7:00 PM – 7:15 PM 62 Planning For Growth – A 2yr Degradation Study Of 3d Printed Polycaprolactone In A Porcine Trachea Model H. Ramaraju¹, V. Adam¹, J. Park¹, B. Steedley¹, A. Kowblansky¹, V. Kulagin¹, G. Green², S. Hollister¹; ¹Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, ²Division of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI. 7:15 PM – 7:30 PM 63 Patient-specific Osteogenesis Imperfecta Bone Organoids Exhibit Similar Stiffness And Mechano-regulation Despite Higher Mineralization J. K. Griesbach¹, A. de Leeuw¹, F. A. Schulte¹, T. Minacci¹, P. J. Lim², M. Rüger³, M. Rohrbach², C. Giunta², M. Rubert¹, R. Müller¹; ¹Institute for Biomechanics, ETH Zürich, Zürich, SWITZERLAND, ²Connective Tissue Unit, Division of Metabolism and Children’s Research Center, University Children’s Hospital Zurich, Zürich, SWITZERLAND, ³Department of Pediatric Orthopaedics and Traumatology, University Children’s Hospital Zurich, Zürich, SWITZERLAND.
Session 19: Biomimetic and Unconventional Biomaterials and Scaffolds for Tissue Repair and Regeneration *Location: Salon E (Fourth Floor)* Session Chairs: Golnaz Karoubi, Gulden Camci-Unal SYIS Co-Chair: Si Han Wang	Oral Presentations: 6:00 PM – 6:15 PM 64 Mussel-inspired Hemostatic Bioadhesive For Wound Healing S. Jain, A. Baidya, N. Annabi; Chemical and Biomolecular Engineering, UCLA, Los Angeles, CA. 6:15 PM – 6:30 PM 65 Mucoadhesive Hydrogels For Treating Oral Diseases S. Choi, J. Jeon, Y. Bae, S. Cho; Biotechnology, Yonsei University, Seoul, KOREA, REPUBLIC OF. 6:30 PM – 6:45 PM 66 Immunomodulatory Effect Of Matrix Bound Nanovesicles (mbv) Upon Myeloid Precursor Cells H. Capella-Monsonis, G. Hussey, S. F. Badylak; Surgery, University of Pittsburgh, PITTSBURGH, PA. 6:45 PM – 7:00 PM 67 A Preclinical Study On The Improvement Of Implant Interface Instability By Drug-loaded Silk Protein Foam Y. Feng¹, K. Liu², T. Wang¹; ¹Department of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi’an, CHINA, ²Shanghai Institute of Microsystem and Information Technology, Shanghai, CHINA. Rapid Fire Presentations: 7:00 PM – 7:05 PM 68 Engineering Therapeutic-loaded, 3D-printed Scaffolds For Local Immunoprotection In Islet Transplantation T. R. Lansberry, R. P. Accolla, J. Liang, J. Walsh, C. L. Stabler; Biomedical Engineering, University of Florida, GAINESVILLE, FL. 7:05 PM – 7:10 PM 69 3D Printed Hybrid Silk Based Scaffolds For Bone Tissue Engineering Against Infections E. Bertoli¹, V. Machain¹, V. E. Bosio^1,2; ¹IFLP, CONICET, La Plata, ARGENTINA, ²Physic Institute of La Plata, National University of La Plata, DIag. 73 esq. 63, ARGENTINA. 7:10 PM – 7:15 PM 70 Bone And Cartilage Microtissue Formation S. Kim^1,2, S. Li¹, J. J. Yoo¹, C. Cha², S. Lee¹;¹Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, ²Department of Materials Science and Engineering, Ulsan National Institute of Science and Technology, Ulsan, KOREA, REPUBLIC OF. 7:15 PM – 7:20 PM 71 Developing A Robust Native Extracellular Matrix To Restore The Pancreatic Islet Basement Membrane, Preserve Islet Function, And Attenuate Islet Immunogenicity For Transplantation H. Wang¹, Q. Dai¹, A. O. Gonzalez¹, O. N. Tran¹, C. Yeh^1,2, D. D. Dean¹, X. Chen^1,3,2; ¹Comprehensive Dentistry, UT Health San Antonio, San Antonio, TX, ²Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX, ³Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, San Antonio, TX. 7:20 PM – 7:25 PM 72 3D Culture Recapitulates An In Vivo Transcriptional Phenotype Of Fibroblastic Reticular Cells In Lymph Nodes As Compared To 2D By Single Cell RNA Sequencing Z. M. Wilkes, L. Teles, A. Tomei; Biomedical Engineering, University of Miami, Coral Gables, FL. 7:25 PM – 7:30 PM 73 Bio-inspired Modification Of Collagen Hydrogels To Achieve High Extensibility And Toughness In Tissue Engineered Auricular Cartilage L. Slyker, L. J. Bonassar; Biomedical Engineering, Cornell University, Ithaca, NY.
Exhibit/Poster Viewing Reception – Poster Session 2 *Location: Gloucester (Third Floor)*	7:30 PM – 9:00 PM
SYIS Social (Ticketed Event – SYIS only) Location: Fairfield, Exeter, & Dartmouth (Third Floor)	9:00 PM – 10:00 PM

Day 3: Thursday

Thursday, April 13, 2023

Registration Open *Location: Atrium (Fourth Floor)*	7:00 AM – 8:00 PM
Plenary Symposium 3: *Location: Salon E & F (Fourth Floor)*	8:00 AM – 9:00 AM Regenerative Approaches for Genetic Disorders Speaker: Dr. Mayana Zatz, PhD, University of São Paulo, Brazil, Biosciences Institute
TERMIS-AM Senior Scientist Award Presentation *Location: Salon E & F (Fourth Floor)*	9:00 AM – 9:30 AM Cellular Engineering Approaches to Understand Neural Rewiring after Injury Speaker: Shelly E. Sakiyama-Elbert, PhD
Coffee Break in Exhibition Hall *Location: Gloucester (Third Floor)*	9:30 AM – 10:00 AM
Scientific Concurrent Sessions 5	10:00 AM – 11:30 AM
Session 20: 3D Tissue-Engineered Cancer Models Part 1 *Location: Salon E (Fourth Floor)* Session Chairs: Rui Reis, Utkan Demirci SYIS Co-Chair: Natalia Theran	Keynote Speaker: 10:00 AM – 10:30 AM – 3D Human Brain Tissue Models to Study Disease David Kaplan 10:30 AM – 10:45 AM – Physical Communication Signals Between Tumors Cells and the Surrounding Extracellular Matrix Josep Samitier 10:45 AM – 11:00 AM – Modelling Key Features of Tumor Microenvironments: How Far We Are? Jai Prakash 11:00 AM – 11:15 AM – Engineering Tumor Associated Vascular Capillaries and Calcified Metastatic Organs-on-a-chip Luiz Bertassoni 11:15 AM – 11:30 AM – Microfluidic Label-free Sorting Technologies for Applications in Medicine: From Isolation of Extracellular Vesicles in Biological Fluids to Microswimmers Utkan Demirci
Session 21: Diverse Experts of Tissue Engineering and Regenerative Medicine: Current Research and Career Paths *Location: Salon G (Fourth Floor)* Session Chairs: Tracy Criswell, Helen Lu SYIS Co-Chair: Mahima Dewani	Keynote Speaker: 10:00 AM – 10:30 AM – Using Imaging Insights to Enhance Musculoskeletal Regeneration Strategies Warren Grayson 10:30 AM – 11:00 AM – Understanding & Re-Writing Stem Cell Programs to “Live Forever” Carlos Aguilar 11:00 AM – 11:30 AM – Bioengineering Human Heart Required Building My Own Heart Doris Taylor
Session 22: Interoception Mediated Musculoskeletal Tissue Regeneration *Location: Salon H-K (Fourth Floor)* Session Chairs: Sarah Greising, Xin Zhao SYIS Co-Chair: Keshav Shah	Keynote Speaker: 10:00 AM – 10:30 AM –Bone Remodeling in Skeletal Disorders and Pain & Biomaterials Dayu Pan Oral Presentations: 10:30 AM – 10:45 AM 74 Central Nervous System (cns)-skeletal Axis Mediated Bone Regeneration Can Be Achieved By Multiple Cations Therapy In Bone Tissue Microenvironment W. Qiao¹, X. Cao², K. Yeung¹; ¹Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, HONG KONG, ²Orthopaedic Surgery, Johns Hopkins University, United States, MD. 10:45 AM – 11:00 AM 75 Gaussian Curvature-driven Direction Of Cell Fate Towards Osteogensis With Triply Periodic Minimal Surface Scaffolds X. Zhao; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, CHINA. 11:00 AM – 11:15 AM 76 Investigating Why “No Pain No Gain” in Implant Dentistry W. Qiao; The University of Hong Kong, Hong Kong, HONG KONG. 11:15 AM – 11:30 AM 77 Injectable Bioactive Hydrogel Composites For Bone Regeneration A. Rubina^1,2, A. Sceglovs^1,2, K. Salma-Ancane^1,2; ¹Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Riga Technical University, Riga, LATVIA, ²Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, LATVIA.
Session 23: Skin Wound and Inflammation Part 2: Basic Science *Location: Salon F (Fourth Floor)* Session Chairs: Hasan Erbil Abaci, Helena Zomer SYIS Co-Chair: Xinyue Gu	Keynote Speaker: 10:00 AM – 10:30 AM – Skin Organoids for Developmental Modeling and Cell Therapy Karl R. Koehler Oral Presentations: 10:30 AM – 10:45 AM 78 3D Culture Of Hematopoietic Stem Cells In Engineered Gelatin Methacrylate Matrices Enhances Granulopoiesis And Neutrophil Antibacterial Action T. Gonzalez-Fernandez¹, E. Cirves¹, A. Vargas¹, K. Leach², S. Simon¹; ¹Biomedical Engineering, University of Claifornia Davis, Davis, CA, ²Orthopaedic Surgery, University of Claifornia Davis, Davis, CA. 10:45 AM – 11:00 AM 79 Tissue-mimetic Hydrogel And Secretome Stratification Identify Key Role Of Exosomes In Regenerative Wound Healing J. Hodge^1,2, J. Robinson^3,1, A. J. Mellott⁴; ¹Bioengineering Graduate Program, University of Kansas, Lawrence, KS, ²Plastic Surgery, University of Kansas Medical Center, Kansas City, KS, ³Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS, ⁴Ronawk Inc., Olathe, KS. 11:00 AM – 11:15 AM 80 Gene-activated Biomaterials To Improve DFU Chronic Wound Healing A. L. Laiva¹, F. J. O’ Brien², M. B. Keogh¹; ¹RCSI Bahrain, Manama, BAHRAIN, ²RCSI, Dublin, IRELAND. 11:15 AM – 11:30 AM 81 Autologous Self-assembled Skin Substitutes For The Treatment Of Acute And Chronic Wounds L. Germain; LOEX Research Centre/Surgery, Université Laval/LOEX, Québec, QC, CANADA.
Transitional Break	11:30 AM – 11:45 AM
SYIS Student Meet Mentor Lunch (Ticketed Event – SYIS Only) *Location: Salon A-D (Third Floor)* Pre–Registration Required. Ticketed Session.	11:45 AM – 1:00 PM TERMIS conferences, the Student-Meet-Mentor Luncheon provides students and young investigators the opportunity to enjoy a multi-course lunch with senior faculty and scientists working in the fields of tissue engineering and regenerative medicine. Mentors will include session chairs, TERMIS faculty members, and local industry leaders.
Lunch (on your own)	11:45 AM – 1:00 PM
FTERM Panel Discussion *Location: Salon E & F (Fourth Floor)* Chair: Molly Shoichet	1:00 PM – 2:00 PM Academic Journeys: Stories from our Fellows of TERM 2023 AM FTERM Inductees: Karen Christman, PhD, Lucie Germain, PhD and Martha Fontanilla, PhD
Transitional Break	2:00 PM – 2:15 PM
Scientific Concurrent Sessions 6	2:15 PM – 3:45 PM
Session 24: Strategies for Regeneration of the Nervous System *Location: Salon H-K (Fourth Floor)* Session Chairs: Nisha Iyer, Mike Modo SYIS Co-Chair: Dzana Katana	Oral Presentations: 2:15 PM – 2:45 PM 82 Subthreshold Epidural Electrical Stimulation (s-ees) Enhances Regeneration When Combined With Cell Loaded Scaffolds And Rehabilitation Following SCI A. M. Siddiqui¹, T. Ammicht², B. K. Chen¹, R. Islam¹, C. A. Cuellar³, B. Knudsen³, P. Summer¹, N. N. Madigan¹, M. J. Yaszemski⁴, I. A. Lavrov¹, A. J. Windebank¹; ¹Neurology, Mayo Clinic, Rochester, MN, ²Neurology, Mayo Cinic, Rochester, MN, ³Neurologic Surgery, Mayo Clinic, Rochester, MN, ⁴Orthopedic Surgery, Mayo Clinic, Rochester, MN. 2:45 PM – 3:00 PM 83 A 3D Human Brain-like Tissue Model Of Neuro-regeneration After Traumatic Brain Injury M. Coe¹, S. Rosenfeld², V. Liaudanskaya³, D. Kaplan¹; ¹Department of Biomedical Engineering, Tufts University, Medford, MA, ²Department of Biopsychology, Tufts University, Medford, MA, ³Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH. 3:00 PM – 3:15 PM 84 MicroRNA-loaded 3D-Printed Hydrogel Scaffolds Towards Effective Neural Tissue Regeneration Following Spinal Cord Injuries K. Lau¹, V. Srirangam Ramanujam^1,2, W. Ju¹, C. Huang¹, S. Chew^1,3,4; ¹School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, SINGAPORE, ²Centre of Scientific Research, Campus for Research Excellence and Technological Enterprise, Singapore, SINGAPORE, ³Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SINGAPORE, ⁴School of Material Science and Engineering, Nanyang Technological University, Singapore, SINGAPORE. 3:15 PM – 3:30 PM 85 Controlled Release Of Chondroitinase Abc In A Rat Model To Treat Chronic Spinal Cord Injury Q. E. Sirianni¹, R. Joseph², L. Weiss², M. A. Hook², M. S. Shoichet¹; ¹Chemical Engineering & Applied Chemistry, The University of Toronto, Toronto, ON, CANADA, ²School of Medicine, Texas A&M University, Bryan, TX. 3:30 PM – 3:45 PM 86 A Hyaluronic Acid-based Hydrogel Culture Platform For Ipsc-derived Midbrain Neuronal Culture Z. Wang¹, Z. Shu², A. Laperle³, C. Svendsen³, N. Maidment², S. Seidlits¹; ¹Biomedical Engineering, University of Texas Austin, Austin, TX, ²Psychiatry & Biobehavior Sciences, University of California Los Angeles, Los Angeles, CA, ³Cedars-Sinai Board of Governors Regenerative Medicine Institute, Los Angeles, CA.
Session 25: Dental and Craniofacial Part 2 *Location: Salon E (Fourth Floor)* Session Chairs: Sang Jin Lee, Weibo Zhang SYIS Co-Chair: Mauricio Sousa	Keynote Speaker: 2:15 PM – 2:45 PM – Biofabrication of Thin Membranes for Craniofacial Tissue Engineering David Dean Oral Presentations: 2:45 PM – 3:00 PM 87 Self-Assembled Hydrogel Microparticle-Based Tooth-Germ Organoids C. Bektas¹, W. Zhang², Y. Mao¹, X. Xu¹, J. KOHN¹, P. Yelick²; ¹Rutgers University, Piscataway, NJ, ²Tufts University, School of Dental Medicine, Boston, MA. 3:00 PM – 3:15 PM 88 3D-printed Platforms For Ligament Orientations In Periodontal Defects Of Canine Model: A Pilot Study C. Park, M. Kim, H. Eom; Dental Biomaterials, Kyungpook National University, Daegu, KOREA, REPUBLIC OF. 3:15 PM – 3:30 PM 89 Using Self-assembled, Tissue-engineered Implants for Treatment of Focal Defects of the Temporomandibular Joint Disc R. P. Donahue¹, B. J. Bielajew¹, N. Vapniarsky², C. M. Heney³, B. Arzi⁴, J. C. Hu¹, K. A. Athanasiou¹; ¹Department of Biomedical Engineering, University of California, Irvine, CA, ²Department of Pathology, Microbiology and Immunology, University of California, Irvine, CA, ³Dentistry and Oral Surgery Service, University of California, Irvine, CA, ⁴Department of Surgical and Radiological Sciences, University of California, Irvine, CA. 3:30 PM – 3:45 PM 90 Biomaterial Adhesive And Novel Delivery For Pediatric Tooth Trauma V. Perez, G. Imran, A. Miri; Biomedical Engineering, NJIT, Newark, NJ.
Session 26: Stem Cells & Cell Therapies & Developmental Biology and Cell Signaling *Location: Salon F (Fourth Floor)* Session Chairs: Nasim Annabi, Gulden Camci-Unal SYIS Co-Chair: Matthew Ishahak	Keynote Speaker: 2:15 PM – 2:45 PM – Cellular Backpacks for Improving Cell Therapies Samir Mitragotri Oral Presentations: 2:45 PM – 3:00 PM 91 Microfluidic Cell Processing For Autologous Photoreceptor Replacement Therapies N. E. Stone^1,2, L. R. Bohrer^1,2, S. Han³, I. Sicher³, T. A. Sulchek⁴, R. F. Mullins^1,2, B. A. Tucker^1,2; ¹Institute for Vision Research, University of Iowa Carver College of Medicine, Iowa City, IA, ²Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA, ³CellFE, Inc, Alameda, CA, ⁴Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA. 3:00 PM – 3:15 PM 92 Age And Sex Differentially Impact The Pro-fibrotic Cellular Response To Synthetic Biomaterials A. N. Rindone, K. B. Stivers, J. H. Michel, P. E. Mensah, J. H. Elisseeff; Johns Hopkins University School of Medicine, Baltimore, MD. 3:15 PM – 3:30 PM 93 Evaluation Of Platelet-rich Plasma Combined Or Not With Hyaluronic Acid On Vaginal Rejuvenation: An Ex-vivo Study S. BERNDT; University of Geneva, Geneva, SWITZERLAND. 3:30 PM – 3:45 PM 94 Electrogenic Gene Dynamics During Forebrain Differentiation From Embryonic Stem Cells L. M. Zirretta¹, A. M. Doyle²; ¹Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Isla Vista, CA, ²Physics of Life Cluster of Excellence, Dresden University of Technology, Dresden, GERMANY.
Session 27: Multi-dimensional Bioprinting and Novel Tissue Patterning Techniques *Location: Salon G (Fourth Floor)* Session Chairs: Ruogang Zhao, Daniel Shiwarski SYIS Co-Chair: Jiannan Li	Keynote Speaker: 2:15 PM – 2:45 PM – 3D Bioprinting Human Tissue and the Path Towards Translation Adam Feinberg Rapid Fire Presentations: 2:45 PM – 2:50 PM 95 Hybprinter-Acoustic (Hybprinter-A) For The Fabrication Of Soft-Rigid Tissue Interfaces J. Li, C. Kim, Y. Yang; Orthopaedic Surgery, Stanford University, Stanford, CA. 2:50 PM – 2:55 PM 96 Multiscale Hybrid Fabrication : Volumetric Printing Meets Two-Photon Ablation R. Rizzo, D. Ruetsche, H. Liu, P. Chansoria, A. Wang, A. Hasenauer, M. Zenobi-Wong; ETH Zurich, Zürich, SWITZERLAND. 2:55 PM – 3:00 PM 97 Role Of Monomer Molecular Structure On DLP-Printed Tissue Constructs H. Goodarzi Hosseinabadi^1,2, L. Ionov², A. Miri¹; ¹Biomedical Engineering, NJIT, Newark, NJ, ²Department of Biofabrication, University of Bayreuth, Bayreuth, GERMANY. 3:00 PM – 3:05 PM 98 Engineering The Gastroesophageal Junction With Aligned Microtissues C. Vogt, A. Panoskaltsis-Mortari; University of Minnesota, Minneapolis, MN. 3:05 PM – 3:10 PM 99 Engineering Human Vascular Beds To Study Endothelial Susceptibility To SARS-CoV-2 C. Robertson, W. Hynes, J. Alvarado, M. Borucki, M. L. Moya; Lawrence Livermore National Laboratory, Livermore, CA. 3:10 PM – 3:15 PM 100 Engineering 3D Printed Biomimetic Osteochondral Scaffolds Y. Kim, S. Alimperti; Georgetown University, Washington, DC. 3:15 PM – 3:20 PM 101 Real-time Measurement Of Cell Concentration And Viability In Bioinks During Bioprinting Using Dielectric Impedance Spectroscopy A. A. Matavosian¹, A. C. Griffin¹, D. B. Bhuiyan², A. M. Lyness², L. J. Bonassar¹; ¹Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, ²R&D, West Pharmaceutical Services, Exton, PA. 3:20 PM – 3:25 PM 102 Poly-l-lysine Molecular Weight Drives Material Properties And Cell Response In 4D Printed Hydrogels S. T. McLoughlin, A. R. McKenna, J. P. Fisher; Fischell Department of Bioengineering, University of Maryland, College Park, MD. 3:25 PM – 3:30 PM 103 In Vivo Robotic Bioprinting Of Vascularized Constructs For The Treatment Of Soft Tissue Injuries J. Quint; University of Connecticut Health Center, Farmington, CT. 3:30 PM – 3: 35 PM 104 Optimization Of Bioprinting Parameters Using Deep Learning For The High Throughput Fabrication Of 3d Organoids J. Shin; Department of Biomedical Engineering, University of Calgary, Calgary, AB, CANADA. 3:35 PM – 3:40 PM 105 Generate The Micro-cluster Confinement Biophysical Micro-environment Using Bioprinting For Cartilage Regeneration In Vitro B. E. Grottkau^1,2, Z. Hui^1,2, Y. Pang^1,2; ¹Orthopaedics, Massachusetts General Hospital, Boston, MA, ²Harvard Medical School, Boston, MA. 3:40 PM – 3:45 PM Q&A
Session 28: Rapid Fire Session 2: Musculoskeletal; Cardiovascular; Cancer/Disease Models *Location: Salon A-D (Fourth Floor)* Session Chairs: Madeleine Oudin	Rapid Fire Presentations: 2:15 PM – 2:20 PM 106 The Potential For Lysyl Oxidase-based Tendon Therapeutics P. K. Nguyen, C. K. Kuo; Fischell Department of Bioengineering, University of Maryland, College Park, MD. 2:20 PM – 2:25 PM 107 Deep Learning-based Osteocyte Identification And Quantification In Histological Images S. Lee¹, H. R. Childs¹, E. Tzoc-Pacheco¹, Y. Naa Ardua Anang¹, S. B. Doty², H. H. Lu¹; ¹Biomedical Enginnering, Columbia University, New York, NY, ²Analytical Microscopy Core Laboratory, Hospital of Special Surgery, New York, NY. 2:25 PM – 2:30 PM 108 Regenerative Engineering Of Complex Extremity Trauma C. Alcazar¹, K. Habing¹, Z. Working¹, N. Willett^1,2, A. Tahayeri¹, L. Bertassoni¹, K. H. Nakayama¹; ¹Oregon Health & Science University, Portland, OR, ²University of Oregon, Eugene, OR. 2:30 PM – 2:35 PM 109 Temporal And Sex-dependent Effect Of Short-term Simulated Microgravity On Human Meniscus Tissue Model Z. Ma; Surgery, University of Alberta, Edmonton, AB, CANADA. 2:35 PM – 2:40 PM 110 Temporal-mandibular Joint Osteoarthritis Alleviated By Platelet-derived Biomaterial And Hyaluronic Acid: From Bench Work To Bedside Y. Deng, B. Peng, W. Deng; Taipei Medical University, Taipei, TAIWAN. 2:40 PM – 2:45 PM Q & A 2:45 PM – 2:50 PM 111 Single Nuclei Analyses Depict Cardiac Preservation Mechanisms Behind Administering Myocardial Matrices J. Mesfin¹, M. Diaz¹, V. Ninh², M. Karkanitsa¹, E. Wong¹, R. Braden¹, C. Luo³, K. King⁴, K. Christman¹; ¹Bioengineering, UC San Diego & Sanford Consortium for Regenerative Medicine, La Jolla, CA, ²School of Medicine, UC San Diego, La Jolla, CA, ³School of Medicine, UC San Diego & Sanford Consortium for Regenerative Medicine, La Jolla, CA, ⁴Bioengineering and School of Medicine, UC San Diego, La Jolla, CA. 2:50 PM – 2:55 PM 112 Design And Fabrication Of A Working Tissue Model Of The Developing Embryonic Heart J. R. Gershlak, K. Miki, H. C. Ott; Surgery, Massachusetts General Hospital, Boston, MA. 2:55 PM – 3:00 PM 113 Cell-only Bioprinting For Blood Vessel Tissue Engineering A. E. Figueroa Milla¹, W. DeMaria¹, D. M. Wells², O. Jeon², E. Alsberg², M. Rolle¹; ¹Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, ²Biomedical Engineering, University of Illinois at Chicago, Chicago, IL. 3:00 PM – 3:05 PM 114 Lymphatic Vessels Tissue Engineering for Treatment of Breast Cancer-Related Lymphedema Q. Zhang, Y. Wu, J. Y. Zhang, M. Schaverien, P. Yu; Plastic Surgery, MD Anderson Cancer Center, Houston, TX. 3:05 PM – 3:10 PM 115 Development Of Surgical Implantation Models For Cellularized 3D-Printed Hydrogel Constructs With Intrinsic Vascular Channels T. Sahakyants^1,2, T. J. Lieberthal¹, C. D. Comer^1,3, N. R. Szabo-Wexler¹, M. J. Hancock⁴, A. P. Spann⁴, C. M. Neville^2,3, J. P. Vacanti^1,2,3; ¹3D BioLabs LLC, Chadds Ford, PA, ²Department of Surgery, Massachusetts General Hospital, Boston, MA, ³Harvard Medical School, Boston, MA, ⁴Veryst Engineering, LLC, Needham, MA. 3:10 PM – 3:15 PM Q & A 3:15 PM – 3:20 PM 116 Recombinant Laminin Proteins Provide A Biologically Relevant Niche For Primary Cellsin Vitro, Mimicking The Natural Niche For Both Adult Stem Cells And Primary Cancer Cells M. Kele¹, Z. Xiao¹, B. Eleuteri¹, T. Kallur²; ¹BD, BioLamina, Sundbyberg, SWEDEN, ²BD, BioLamina, Cambridge, MA. 3:20 PM – 3:25 PM 117 Genetically Engineering Brain Organoids To Model Glioblastoma M. Ishahak, A. H. Kim, J. R. Millman; Washington University in St. Louis, St. Louis, MO. 3:25 PM – 3:30 PM 118 Elucidating The Mechanisms By Which Chemotherapy Treatment Induces Pro-invasive Changes In The Extracellular Matrix A. Yui¹, J. P. Fatherree², R. A. McGinn¹, M. J. Oudin¹; ¹Biomedical Engineering, Tufts University, Medford, MA, ²Cell, Molecular and Developmental Biology, Tufts University, Medford, MA. 3:30 PM -3:35 PM 119 Engineered Hydrogel For Studying Astrocyte Response To Glioblastoma Derived Extracellular Vesicles T. DePalma^1,2, K. Hughes¹, M. Tawkif¹, C. Hisey¹, A. Skardal^1,2; ¹Biomedical Engineering, The Ohio State University, Columbus, OH, ²The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, OH. 3:35 PM – 3:40 PM 120 Patient-derived Tumor Organoids To Evaluate Tumor-specific ECM Architecture N. Edenhoffer¹, G. Nomdedeu¹, X. Gu^1,2, K. Votanopoulos³, S. Soker¹; ¹Wake Forest Institute for Regenerative Medicine, Wake Forest Graduate School of Arts and Sciences, Winston-Salem, NC, ²Johns Hopkins, Baltimore, MD, ³Department of General Surgery, Wake Forest University, Winston-Salem, NC. 3:40 PM – 3:45 PM Q & A
Coffee Break in Exhibit Hall *Location: Gloucester (Third Floor)*	3:45 PM – 4:15 PM
Educational, Training and Outreach Award Presentation *Location: Salon E & F (Fourth Floor)*	4:15 PM – 4:45 PM Sprouting Careers in Regenerative Medicine: Past, Present, and Future Speaker; Joan F. Schanck, MPA
WFIRM Young Investigator Awards Presentations *Location: Salon E & F (Fourth Floor)*	4:45 PM – 5:15 PM Award Recipients: Lexi Rindone and Jacob Hodge
Exhibit/Poster Viewing Reception – Poster Session 3 *Location: Gloucester (Third Floor)*	5:15 PM – 7:15 PM
TERMIS-AM Thematic Working Interest Groups (TWIGs) Organizational Meeting *Location: Salon E & F (Fourth Floor)*	5:20 PM – 5:50 PM All conference attendees are invited to learn more about TWIGs and how to get involved. TWIGs are a great way to participate more in TERMIS-AM within thematic areas that align with your research interests.
Evening Conference Reception Location: Atrium & Atrium Lounge (Third Floor)	7:15 PM – 9:15 PM SYIS Career Development & Scientific Excellence Award Presentation (8:30 PM – 8:45 PM)

Day 4: Friday

Friday, April 14, 2023

Registration Open *Location: Atrium (Fourth Floor)*	7:30 AM – 12:00 PM
Scientific Concurrent Sessions 7	8:00 AM – 9:30 AM
Session 29: Tissue Engineered Ocular Tissues for Disease Modeling and Cell Therapies *Location: Salon H-K (Fourth Floor)* Session Chairs: Kapil Bharti, Budd Tucker	Keynote Speaker: 8:00 AM – 8:30 AM Advancing Drug Discovery with Bioprinted Retina Tissue Models Marc Ferrer Oral Presentations: 8:30 AM – 8:45 AM 121 Treatment Of Glaucoma And Optic Nerve Trauma Using Matrix-bound Nanovesicles And Fluvastatin M. J. Dewey¹, B. Chirravuri², J. Chang², T. Kuwajima³, G. Campbell³, Y. van der Merwe⁴, G. Hussey⁵, F. Nurefsan Selek⁶, F. Sumeyye Demirhan⁶, G. Bramblett⁶, R. Sappington⁷, F. Zor⁶, Y. Kulahci⁶, V. Gorantla⁶, S. Badylak²; ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Surgery, University of Pittsburgh, Pittsburgh, PA, ³Opthalmology, University of Pittsburgh, Pittsburgh, PA, ⁴Bioengineering, University of Pittsburgh, Pittsburgh, PA, ⁵Pathology, University of Pittsburgh, Pittsburgh, PA, ⁶Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, ⁷Biochemistry and Opthalmology, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC. 8:45 AM – 9:00 AM 122 Exploiting Advanced Cell Culture Technology To Accelerate Production Of Therapeutic Biologics A. M. Medina-Lopez, J. G. Nelson-Brantley, H. E. Decker, A. J. Mellott; Research and Development, Ronawk, olathe, KS. Rapid Fire Presentations: 9:00 AM – 9:05 AM 123 3D Bioprinting Of Corneal-Cell Laden Inks As Bioengineered Corneal Substitutes L. G. Brunel¹, S. M. Hull¹, G. Fernandes-Cunha², P. K. Johansson³, D. Myung², S. C. Heilshorn³; ¹Chemical Engineering, Stanford University, Stanford, CA, ²Ophthalmology, Stanford University, Stanford, CA, ³Materials Science and Engineering, Stanford University, Stanford, CA. 9:05 AM – 9:10 AM 124 Functionalised PEG-based Hydrogel Films For Human Corneal Endothelial Tissue Engineering K. D. Brown¹, J. D. Palmer¹, J. Finnigan², P. Gurr², J. Montenegro¹, G. Dusting¹, G. Qiao², M. D. Daniell¹; ¹Surgical Research Unit, Centre for Eye Research Australia, East Melbourne, AUSTRALIA, ²Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, AUSTRALIA. 9:10 AM – 9:15 AM 125 A Multimodal Neuroprotective Stem Cell Tissue Engineering Solution For Treating Retinitis Pigmentosa P. Colombe Dromel¹, D. Singh^1,2; ¹InGel Therapeutics, Allston, MA, ²Harvard Medical School, Boston, MA. 9:15 AM – 9:20 AM 126 Enhanced Corneal Wound Healing On Plasma Processed Electrospun Scaffolds L. McLarnon, G. A. Burke; Engineering, Ulster Univeristy, Belfast, UNITED KINGDOM. 9:20 AM – 9:25 AM 127 Decellularization Process Development for Fish Cornea L. S. Marques¹, W. S. Barroso², F. K. Andrade¹, V. Lima³, R. S. Vieira⁴; ¹Chemical Engineering Department, Federal University of Ceará, Fortaleza, BRAZIL, ²Biochemistry and Molecular Biology Department, Federal University of Ceará, Fortaleza, BRAZIL, ³Physiology and Pharmacology Department, Federal University of Ceará, Fortaleza, BRAZIL, ⁴Department of Chemical Engineering, Federal University of Ceará, Fortaleza, BRAZIL. 9:25 AM – 9:30 AM 128 Ipsc-derived 3d Outer Blood Retinal Barrier Formed By Rpe And Choroid For In Vitro Amd Modeling T. Park, R. Quinn, R. Hirday, A. Ali, E. Nguyen, D. Bose, R. Sharma, K. Bharti; NIH, Bethesda, MD.
Session 30: Building Networks: Advances in Tissue and Organ Vascularization *Location: Salon G (Fourth Floor)* Session Chairs: Milica Radisic, Boyang Zhang SYIS Co-Chair: Jaemyung (Jenny) Shin	Keynote Speaker: 8:00 AM – 8:30 AM – Engineering Vascularization Using Biomaterials Christopher Chen 8:30 AM – 9:00 AM – Building Tissues with Microvascular Support Ying Zheng Oral Presentations: 9:00 AM – 9:15 AM 129 Modeling The Earliest Stages Of Human Cardiac And Hepatic Vascularization O. J. Abilez¹, H. Yang², K. D. Wilson³, E. H. Lyall³; ¹Pediatric Cardiac Surgery, Stanford University, Stanford, CA, ²Biomedical Engineering, University of North Texas, Denton, TX, ³Rosebud Biosciences, San Carlos, CA. 9:15 AM – 9:30 AM 130 Heart-on-a-chip With Vascular Plexus For Drug Testing Y. Zhao¹, M. Radisic¹, G. Vunjak-Novakovic²; ¹University of Toronto, Torono, ON, CANADA, ²Columbia University, New York City, NY.
Session 31: Organ-on-chip/Bioreactor *Location: Salon E (Fourth Floor)* Session Chairs: Julio Aleman, Pedro Costa SYIS Co-Chair: Ramaraju Harsha	Keynote Speaker: 8:00 AM – 8:30 AM – Bioengineered Brain Vascular Network for Neural Stem Cell and Brain Tumor Research Guohao Dai Oral Presentations: 8:30 AM – 8:45 AM 131 Unlocking The Potential Of Organ-on-chip For Drug Development And Discovery Through Precision Microfluidics, Integrated Sensing, And High-throughput Platforms T. A. Petrie; Biosystems and Cell Engineering, Draper, Cambridge, MA. 8:45 AM – 9:00 AM 132 3D Bioprinted Perfusable Endothelialized Liver Tissue Constructs Y. Moon, K. Willson, C. Bishop, A. Atala, J. J. Yoo, S. Lee; WFIRM, Wakeforest University, Winston Salem, NC. 9:00 AM – 9:15 AM 133 Next Generation Glomerulus-on-a-chip For Disease Modeling X. Mou, J. Shah, S. Musah; Biomedical Engineering, Duke University, Durham, NC. 9:15 AM – 9:30 AM 134 Mucosal Tissue Bioreactor For Studying HEMT-nonresponsive Cystic Fibrosis M. R. Hudock¹, T. Baines, III², M. R. Pinezich¹, O. P. Gavaudan¹, P. Chen¹, J. Van Hassel¹, M. Diane¹, J. Chen³, S. Mir³, J. Kim³, G. Vunjak-Novakovic^1,4; ¹Biomedical Engineering, Columbia University, New York, NY, ²Engineering, Morehouse College, Atlanta, GA, ³Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, ⁴Medicine, Columbia University, New York, NY.
Session 32: Measuring and Modelling Tissue Aging, Rejuvenation and Regeneration *Location: Salon F (Fourth Floor)* Session Chair: Irene de Lazaro	Keynote Speaker: 8:00 AM – 8:30 AM – Quantifying Tissue Aging and Rejuvenation Vadim Gladyshev Oral Presentations: 8:30 AM – 8:45 AM 157 Investigating Brain Tissue Mechanics As A Neural Regeneration Strategy For Alzheimer’s Disease S. Lasli¹, C. Hall^1,2, G. Sheridan³, E. Moeendarbary¹; ¹Department of Mechanical Engineering, University College London, London, UNITED KINGDOM, ²School of Applied Sciences, University of Brighton, Brighton, UNITED KINGDOM, ³School of Life Sciences, University of Nottingham, Nottingham, UNITED KINGDOM. 8:45 AM – 9:00 AM 158 Impairment In Nascent Matrix Deposition Of Muscle Stem Cells During Aging P. Duran^1,2, C. Loebel^1,2,3, C. A. Aguilar^1,2; ¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, ²Biointerfaces Institute, Ann Arbor, MI, ³Materials Science and Engineering, University of Michigan, Ann Arbor, MI. 9:00 AM – 9:15 AM 135 The Development Of A Synaptic Long Term Potential Model Utilizing Human Ipsc-cortical Neurons For Alzheimer’S Drug Evaluation K. Autar¹, J. Caneus², X. Guo², N. Akanda², M. Jackson¹, W. Bogen¹, C. Long¹, S. Lindquist¹, D. Morgan³, J. J. Hickman¹; ¹Biology, Hesperos, Inc., Orlando, FL, ²Nanoscience Technology Center, University of Central Florida, Orlando, FL, ³Translational Neuroscience, Michigan State University, Grand Rapids, MI. 9:15 AM – 9:30 AM 136 Biomaterials-based Delivery Of Induced Pluripotent Stem Cell-derived Smooth Muscle Cells For Treatment Of Murine Abdominal Aortic Aneurysm M. Shayan¹, J. Mulorz², C. Hu³, P. Tsao², N. F. Huang¹; ¹Cardiothoracic Surgery, Stanford University, Stanford, CA, ²Cardiovascular Medicine, Stanford University, Stanford, CA, ³Veterans Affairs Palo Alto Health Care System, Stanford, CA.
Session 33: Engineering and Regeneration of Airway, Digestive, or Urogenital Systems *Location: Salon A-D (Fourth Floor)* Session Chairs: Riccardo Gottardi, Andreas Kaasi SYIS Co-Chair: Jonathan Dorogin	Oral Presentations: 8:00 AM – 8:15 AM 137 Artificialmitochondriatransfer As A New Tool To Enhance Regeneration And Repair In An In Vitro Model Of Renal Tubular Injury And In An Ex Vivo Porcine Model Of Dcd Renal Transplantation A. Asthana¹, A. Rossi¹, L. N. BYERS¹, F. MONTALI¹, J. MILLER¹, J. Bowlby¹, J. Robertson², R. SENGER², L. PERIN³, S. SERDAKYAN³, C. Aardema⁴, B. Bussolati⁵, G. Orlando¹; ¹Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, ²VA TECH, BLACKSBURG, VA, ³USC, LOS ANGELES, CA, ⁴VA TECH, Winston Salem, NC, ⁵University of Turin, Turin, ITALY. 8:15 AM – 8:30 AM 138 Restoring Laryngeal Biomechanics After Inhalational Burn Injury G. Cervantes-Gonzales, T. Guda, A. Isaac; Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX. 8:30 AM – 8:45 AM 139 Regenerative Of Urethral Sphincter Deficiency By Injection Of Cells In A Pig Large Animal Model Of Stress Urinary Incontinence J. Knoll, N. Harland, B. Amend, A. Stenzl, W. K. Aicher; Urology, University of Tübingen, Tübingen, GERMANY. 8:45 AM – 9:00 AM 140 A Study To Determine The Feasibility Of Using Human Es Cell-derived Cartilage To Augment Repair Of Tracheal Stenosis M. Komura¹, J. Chen², H. Komura¹, R. Itou², S. Enosawa², A. Umezawa², Y. Fuchimoto³; ¹the University of Tokyo, Tokyo, JAPAN, ²National Center for child Health and development, Tokyo, JAPAN, ³International University of Health and Welfare, Chiba, JAPAN. Rapid Fire Presentations: 9:00 AM – 9:05 AM 141 Decellularized Cartilage For Laryngotracheal Reconstruction In A Neonatal Pig Model P. Gehret¹, A. Dumas¹, I. Jacobs², R. Gottardi^1,2; ¹Bioengineering, University of Pennsylvania, Philadelphia, PA, ²Children’s Hospital of Philadelphia, Philadelphia, PA. 9:05 AM – 9:10 AM 142 Effect Of Liver Matrix Age On Hepatocyte And Hepatic Non-Parenchymal Cells Recovery From Static Cold Storage B. W. Ellis, H. Chen, M. Mojoudi, K. Uygun, B. E. Uygun; Surgery, Massachusetts General Hospital, Boston, MA. 9:10 AM – 9:15 AM 143 Optimization Of Co-cultures Of Primary Hepatocytes, Endothelial Cells, And Mesenchymal Stem Cells For Use In A Liver Tissue Engineered Millifluidic Hydrogel T. J. Lieberthal¹, N. Szabo-Wexler¹, T. Sahakyants¹, C. M. Neville², J. P. Vacanti³; ¹3D BioLabs, LLC, Chadds Ford, PA, ²Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, ³Department of Surgery, Massachusetts General Hospital, Boston, MA. 9:15 AM – 9:20 AM 144 Engineered Lung Microtissue To Model Macrophage-regulated Pulmonary Fibrosis And Anti-fibrosis Treatment Y. Xu, R. Zhao; Biomedical Engineering, University at Buffalo, Buffalo, NY. 9:20 AM – 9:25 AM 145 In Vitro Assessment Of Radiation Exposure On Primary Human Bronchial Epithelial Cells D. Lizanets^1,2, S. V. Murphy^1,2, A. R. Hall^1,2,3; ¹Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, ²Virginia Tech – Wake Forest School of Biomedical Engineering and Sciences, Winston Salem, NC, ³Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC.
Coffee Break *Location: Ballroom Foyer (Fourth Floor)*	9:30 AM – 9:45 AM
Scientific Concurrent Sessions 8	9:45 AM – 11:15 AM
Session 34: Tissue Chips in Space to Benefit Life on EarthLocation: Salon A-D (Fourth Floor) Session Chairs: Lisa Larkin, Riccardo Gottardi	Keynote Speaker: 9:45 AM – 10:07 AM – Opportunities and Challenges for Tissue Engineering in Low Earth Orbit Stephanie George 10:07 AM – 10:30 AM – Muscle Tissue Chips in Space: What Can Microgravity Tell Us About Muscle Loss and Paths to Commercialization Siobhan Malany 10:30 AM – 10:52 AM – Utilising Microgravity to Understand and Modify Skeletal Muscle Ageing Anne McArdle 10:52 AM – 11:15 AM – Human Cartilage-Bone-Synovium Microphysiological System for Post-Traumatic Osteoarthritis on Earth and in Space Alan Grodzinsky
Session 35: Engineering and Commercialization of Lab-Grown Meat *Location: Salon H-K (Fourth Floor)* Session Chairs: Ruogang Zhao, Antonella Motta	Keynote Speaker: 9:45 AM – 10:15 AM – The Future of Food is in Your Hands: Tissue Engineering for Cultivated Meat & Seafood Claire Bomkamp 10:15 AM – 10:45 AM – Cellular Agriculture: Growing Meat in the Lab Glenn Gaudette 10:45 AM – 11:15 AM – TBD TBD
Session 36: MXenes: The Next Generation Nanomaterials for Regenerative Medicine and Immunoengineering *Location: Salon E (Fourth Floor)* Session Chairs: Sanjiv Dhingra, Acelya Yilmager Aktuna	Keynote Speaker: 9:45 AM – 10:15 AM – Synthesis and Properties of MXenes for Biomedical Applications Yury Gogotsi 10:15 AM – 10:45 AM – MXene Based Immuno-engineering Approaches to Prevent Rejection of Transplanted Stem Cells and Solid Organ Sanjiv Dhingra Oral Presentations: 10:45 AM – 11:00 AM 146 Shmt1 Sirna-loaded Hyperosmotic Nanochains For Blood-brain/tumor Barrier Post-transmigration Therapy S. Pandey, M. Lee, P. Garg, J. Chung; Department of Biosystems Engineering, Seoul national University, Seoul, KOREA, REPUBLIC OF. 11:00 AM – 11:15 AM 147 Development of Biomaterials Based on Carbon-graphene Association to Bone Tissue Engineering D. F. BUENO¹, P. Almeida², G. L. Achôa³, J. R. Ferreira⁴, A. Hokugo⁵, A. Clements⁵, T. L. Fernandes⁶, R. Jarrahy⁷, G. F. Silva⁸; ¹Stem cell and tissue engineering to craniofacial malformation, Universidade Corporativa ANADEM/Hospital Municipal Infantil Menino Jesus/ Hospital Sírio-Libanês, Brasília ; SÃO PAULO**, BRAZIL, ²Material Engineering, POLI-USP, São Paulo, BRAZIL, ³Stem cell and tissue engineering to craniofacial malformation, Hospital Sírio-Libanês, São Paulo, BRAZIL, ⁴Stem cell and tissue engineering to craniofacial malformation, Universidade Corporativa ANADEM, Brasília, BRAZIL, ⁵Stem cell and tissue engineering to craniofacial malformation, UCLA, Los Angeles, CA, ⁶Stem cell and tissue engineering to craniofacial malformation, Hospital Sírio-Libanês, SÃO PAULO, BRAZIL, ⁷Plastic Surgery, UCLA, Los Angeles, BRAZIL, ⁸Material Engineering, POLI-USP, SÃO PAULO, BRAZIL.
Session 37: Noninvasive Imaging and Assessment Tools for Evaluating Biomaterials and Engineered Tissues *Location: Salon G (Fourth Floor)* Session Chairs: Marcella Vaicik, Mrignayani Kotecha SYIS Co-Chair: Julia Griesbach	Keynote Speaker: 9:45 AM – 10:15 AM – Image-informed Tissue Engineering – The Next Frontier in Bioengineering Arvind P. Pathak 10:15 AM – 10:45 AM – Multimodality Molecular Imaging of the Tissue Microenvironment Marty Pagel Oral Presentations: 10:45 AM – 11:00 AM 148 Novel High Throughput Image-based Prediction Of M1, M2a And M2c Macrophage Phenotypes And IL-10 Production Based On Quantification Of Single Cell Morphology M. L. Hart, M. Selig, L. Poehlman, M. Völker, B. Rolauffs; Orthopedics and Trauma Surgery, G.E.R.N. Center for Tissue Replacement, Regeneration & Neogenesis, Freiburg, GERMANY. 11:00 AM – 11:15 AM 149 Nondestructive Real Time Cell Viability Assessment Using Oxygen Imaging S. Hameed¹, N. Viswakarma¹, E. Siddiqui¹, B. Epel^2,1, M. Kotecha¹; ¹O2M Technologies, LLC, Chicago, IL, ²Radiation and Cellular Oncology, The University of Chicago, Chicago, IL.
Session 38: Bioengineered in Vitro Cancer Models: Modeling the Complexity of Cancer in Tumor Organoids, Tumor Constructs, and Tumor-on-a-chip *Location: Salon F (Fourth Floor)* Session Chairs: Aleksander Skardal, Shay Soker SYIS Co-Chair: Sydney Conner	Oral Presentations: 9:45 AM – 10:00 AM 150 An Engineered In Vitro Hydrogel Model Recapitulates The Molecular Signatures Of Invasion In Glioblastoma A. Skirzynska, L. J. Smith, M. S. Shoichet; Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA. 10:00 AM – 10:15 AM 151 Enhancing Immunotherapy Via Chemokine-driven Natural Killer Cells In 3d Melanoma Organ-on-a-chip Platform S. Chakraborty¹, A. Skardal^1,2, A. Vilgelm^3,2, A. Davies^4,2, V. Bharti³; ¹Biomedical Engineering, The Ohio State University, Columbus, OH, ²Ohio State University Comprehensive Cancer Centre, Columbus, OH, ³Pathology, The Ohio State University, Columbus, OH, ⁴Veterinary Biosciences, The Ohio State University, Columbus, OH. 10:15 AM – 10:30 AM 152 The Role Of Trans-endothelial Flow On Pd-l1 Expression In The Tumor Microenvironment Z. Wan¹, S. Zhang¹, D. A. Barbie², R. D. Kamm¹; ¹MIT, Cambridge, MA, ²Dana-Farber Cancer Institute, Boston, MA. 10:30 AM – 10:45 AM 153 Investigation Of The Role Of Extracellular Matrix Changes In Breast Cancer Progression Using 3D Collagen-based Scaffold Models E. Sainsbury, F. J. O’Brien, C. M. Curtin; Royal College of Surgeons, Dublin, IRELAND. 10:45 AM – 11:00 AM 154 Next Generation Tumor Explant Technologies For Personalized Medicine C. Adine¹, K. Fernando², N. Ho², N. Iyer^3,4, E. Fong^1,2,5; ¹The N.1 Institute for Health, National University of Singapore, Singapore, SINGAPORE, ²Biomedical Engineering, National University of Singapore, Singapore, SINGAPORE, ³Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, Singapore, SINGAPORE, ⁴Duke-NUS Medical School, National University of Singapore, Singapore, SINGAPORE, ⁵Cancer Science Institute, National University of Singapore, Singapore, SINGAPORE. 11:00 AM – 11:15 AM 155 Personalized Immunocompetent Tumor-on-a-Chip Platform Produces Tumor-Reactive Cytotoxic Lymphocytes D. C. Hutchins¹, C. R. Schaaf², N. Edenhoffer¹, M. Kooshki³, A. R. Hall⁴, L. Miller³, P. Triozzi⁵, S. Soker¹, K. Votanopoulos⁶; ¹Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ²Department of Pathology, Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ³Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, ⁴Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, ⁵Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, ⁶Surgery Oncology, Wake Forest School of Medicine, Winston-Salem, NC.
Transitional Break	11:15 AM – 11:30 AM
Closing Ceremony *Location: Salon E & F (Fourth Floor)*	11:30 AM – 11:45 AM
Lunch (on your own)	11:45 AM – 1:00 PM
SYIS Career Panel Discussion *Location: Salon H-K (Fourth Floor)*	1:00 PM – 2:30 PM